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dc.date.accessioned 2023-10-23T14:07:29Z
dc.date.available 2023-10-23T14:07:29Z
dc.date.issued 2003
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/159211
dc.description.abstract A mass spectrometric study of the photooxidation products of the ophthalmic drugs pindolol (1-[1H-indol-4-yloxyl]-3-[isopropylamino]-2-propanol) and timolol (S-[-]-1-[t-butylamino]-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxyl]-2-propanol) in water has been performed by LC-MS. Based on these data and the assumption that photooxidation mainly occurs through singlet molecular oxygen attack, a possible reaction mechanism is proposed. The mechanistic pathways involve singlet oxygen attack to the pindolol indole ring and oxidation of the pindolol isopropyl or timolol terbutyl methyl groups. en
dc.format.extent 551-553 es
dc.language en es
dc.subject photooxidation es
dc.subject pindolol es
dc.subject reaction mechanism es
dc.title Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol en
dc.type Articulo es
sedici.identifier.issn 0031-7144 es
sedici.creator.person Criado, Susana es
sedici.creator.person Mártire, Daniel Osvaldo es
sedici.creator.person Allegretti, Patricia Ercilia es
sedici.creator.person Furlong, Jorge Javier Pedro es
sedici.creator.person Bertolotti, Sonia es
sedici.creator.person La Falce, E es
sedici.creator.person García, Norman es
sedici.subject.materias Química es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas es
mods.originInfo.place Laboratorio de Estudio de Compuestos Orgánicos es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Pharmazie es
sedici.relation.journalVolumeAndIssue vol. 58, no. 8 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)