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dc.date.accessioned | 2023-11-07T14:50:24Z | |
dc.date.available | 2023-11-07T14:50:24Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/159865 | |
dc.description.abstract | SARS-CoV-2, the seventh coronavirus known to infect humans, can cause severe life-threatening respiratory pathologies. To better understand SARS-CoV-2 evolution, genome-wide analyses have been made, including the general characterization of its codons usage profile. Here we present a bioinformatic analysis of the evolution of SARS-CoV-2 codon usage over time using complete genomes collected since December 2019. Our results show that SARS-CoV-2 codon usage pattern is antagonistic to, and it is getting farther away from that of the human host. Further, a selection of deoptimized codons over time, which was accompanied by a decrease in both the codon adaptation index and the effective number of codons, was observed. All together, these findings suggest that SARS-CoV-2 could be evolving, at least from the perspective of the synonymous codon usage, to become less pathogenic. | en |
dc.language | en | es |
dc.subject | Codon usage bias | es |
dc.subject | SARS-CoV-2 | es |
dc.subject | COVID-19 | es |
dc.subject | Betacoronavirus | es |
dc.title | Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemic | en |
dc.type | Articulo | es |
sedici.identifier.other | https://doi.org/10.1016/j.virol.2022.01.011 | es |
sedici.identifier.issn | 1096-0341 | es |
sedici.creator.person | Mogro, Ezequiel Gerardo | es |
sedici.creator.person | Bottero, Daniela | es |
sedici.creator.person | Lozano, Mauricio Javier | es |
sedici.subject.materias | Biología | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Instituto de Biotecnología y Biología Molecular | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Virology | es |
sedici.relation.journalVolumeAndIssue | vol. 568 | es |