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dc.date.accessioned 2023-11-07T14:50:24Z
dc.date.available 2023-11-07T14:50:24Z
dc.date.issued 2022
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/159865
dc.description.abstract SARS-CoV-2, the seventh coronavirus known to infect humans, can cause severe life-threatening respiratory pathologies. To better understand SARS-CoV-2 evolution, genome-wide analyses have been made, including the general characterization of its codons usage profile. Here we present a bioinformatic analysis of the evolution of SARS-CoV-2 codon usage over time using complete genomes collected since December 2019. Our results show that SARS-CoV-2 codon usage pattern is antagonistic to, and it is getting farther away from that of the human host. Further, a selection of deoptimized codons over time, which was accompanied by a decrease in both the codon adaptation index and the effective number of codons, was observed. All together, these findings suggest that SARS-CoV-2 could be evolving, at least from the perspective of the synonymous codon usage, to become less pathogenic. en
dc.language en es
dc.subject Codon usage bias es
dc.subject SARS-CoV-2 es
dc.subject COVID-19 es
dc.subject Betacoronavirus es
dc.title Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemic en
dc.type Articulo es
sedici.identifier.other https://doi.org/10.1016/j.virol.2022.01.011 es
sedici.identifier.issn 1096-0341 es
sedici.creator.person Mogro, Ezequiel Gerardo es
sedici.creator.person Bottero, Daniela es
sedici.creator.person Lozano, Mauricio Javier es
sedici.subject.materias Biología es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Biotecnología y Biología Molecular es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Virology es
sedici.relation.journalVolumeAndIssue vol. 568 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)