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dc.date.accessioned | 2023-11-23T17:21:54Z | |
dc.date.available | 2023-11-23T17:21:54Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/160474 | |
dc.description.abstract | Photosensitized oxidations, in part responsible for the harmful effect of UV and visible radiation on biological systems, can take place through type I (generation of radicals) and type II (singlet oxygen) mechanisms. Pterins are heterocyclic compounds, widespread in living systems and involved in relevant biological functions. Pterins present a profuse and amazing photochemistry and are endogenous photosensitizers that act mainly via type I mechanism. This survey is aimed to contribute to a better understanding on the complex set of competitive pathways involved in type I photosensitization. Based on studies performed in model systems with pterins as photosensitizers, this review explores the mechanisms involved in the type I photooxidations of proteins, DNA and lipids sensitized by pterins. The generation of radicals and their subsequent reactions are described together with the analysis of the role of O 2 and reactive oxygen species. The chemical modification of pterins seeking for better properties and the effect of the photochemical processes at a cellular level are also analyzed. | en |
dc.language | en | es |
dc.subject | pterins | es |
dc.subject | photosensitization | es |
dc.subject | singlet oxygen | es |
dc.subject | radicals | es |
dc.subject | photooxidation | es |
dc.title | A model to understand type I oxidations of biomolecules photosensitized by pterins | en |
dc.type | Articulo | es |
sedici.identifier.other | https://doi.org/10.1016/j.jpap.2021.100045 | es |
sedici.identifier.issn | 2666-4690 | es |
sedici.creator.person | Lorente, Carolina | es |
sedici.creator.person | Serrano, Mariana Paula | es |
sedici.creator.person | Vignoni, Mariana | es |
sedici.creator.person | Dántola, María Laura | es |
sedici.creator.person | Thomas, Andrés Héctor | es |
sedici.subject.materias | Química | es |
sedici.subject.materias | Biología | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Journal of Photochemistry and Photobiology | es |
sedici.relation.journalVolumeAndIssue | vol. 7 | es |