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dc.date.accessioned 2023-11-23T17:21:54Z
dc.date.available 2023-11-23T17:21:54Z
dc.date.issued 2021
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/160474
dc.description.abstract Photosensitized oxidations, in part responsible for the harmful effect of UV and visible radiation on biological systems, can take place through type I (generation of radicals) and type II (singlet oxygen) mechanisms. Pterins are heterocyclic compounds, widespread in living systems and involved in relevant biological functions. Pterins present a profuse and amazing photochemistry and are endogenous photosensitizers that act mainly via type I mechanism. This survey is aimed to contribute to a better understanding on the complex set of competitive pathways involved in type I photosensitization. Based on studies performed in model systems with pterins as photosensitizers, this review explores the mechanisms involved in the type I photooxidations of proteins, DNA and lipids sensitized by pterins. The generation of radicals and their subsequent reactions are described together with the analysis of the role of O 2 and reactive oxygen species. The chemical modification of pterins seeking for better properties and the effect of the photochemical processes at a cellular level are also analyzed. en
dc.language en es
dc.subject pterins es
dc.subject photosensitization es
dc.subject singlet oxygen es
dc.subject radicals es
dc.subject photooxidation es
dc.title A model to understand type I oxidations of biomolecules photosensitized by pterins en
dc.type Articulo es
sedici.identifier.other https://doi.org/10.1016/j.jpap.2021.100045 es
sedici.identifier.issn 2666-4690 es
sedici.creator.person Lorente, Carolina es
sedici.creator.person Serrano, Mariana Paula es
sedici.creator.person Vignoni, Mariana es
sedici.creator.person Dántola, María Laura es
sedici.creator.person Thomas, Andrés Héctor es
sedici.subject.materias Química es
sedici.subject.materias Biología es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Journal of Photochemistry and Photobiology es
sedici.relation.journalVolumeAndIssue vol. 7 es


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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)