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dc.date.accessioned 2024-03-20T18:03:17Z
dc.date.available 2024-03-20T18:03:17Z
dc.date.issued 2003
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/164076
dc.description.abstract To assess the effect of histoneH3on pituitary hormone secretion, rat anterior pituitary (AP) cells were used and growth hormone, prolactin, thyrotropin, luteinizing hormone and follicle stimulating hormone measured by radioimmunoassay. Incubation of cells with H3 (1, 6, and 30mM) stimulated the release of all five hormones in a dose-dependent manner. This effect was blocked by preincubation of H3 with an anti-H3 antibody. Incubation of AP cells with 6mMH3 in the presence of specific AP hormone secretagogues (GRP-6, thyrotropin-releasing hormone (TRH), gonadotropin-releasing hormone (GnRH)) showed additive effects on hormone secretion. Pharmacological experiments suggested that calcium- and diacylglycerol- (DAG) associated pathways, but not cAMP, participate in the hypophysiotropic activity of H3. Our results confirm previous evidence that histones may act as hypophysiotropic signals. en
dc.format.extent 671-678 es
dc.language en es
dc.subject Histones es
dc.subject Hypophysotropic activity es
dc.subject Pituitary cells es
dc.subject Second messengers es
dc.subject Apoptotic signals es
dc.title Hypophysotropic activity of histone H3 in vitro en
dc.type Articulo es
sedici.identifier.other doi:10.1016/S0196-9781(03)00132-3 es
sedici.identifier.issn 0196-9781 es
sedici.creator.person Brown, Oscar Alfredo es
sedici.creator.person Sosa, Yolanda Elena es
sedici.creator.person Naumovich, Diana es
sedici.creator.person Hereñú, Claudia Beatriz es
sedici.creator.person Goya, Rodolfo Gustavo es
sedici.subject.materias Bioquímica es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Investigaciones Bioquímicas de La Plata es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Peptides es
sedici.relation.journalVolumeAndIssue vol. 24 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)