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dc.date.accessioned 2012-05-14T19:42:32Z
dc.date.available 2012-05-14T19:42:32Z
dc.date.issued 2012
dc.identifier.uri http://hdl.handle.net/10915/18099
dc.description.abstract A simple and sensitive high-performance liquid chromatography (HPLC) method was developed and validated for the determination of auraptene (AUR) in dog plasma. The chromatographic separation of AUR was achieved on a C18 column using isocratic elution with acetonitrile-0.1 % formic acid (volume ratio 84.5:15.5). AUR was detected at 322 nm. Sample extraction with ethyl acetate resulted in high recoveries of AUR. A linear curve over the concentration range 10.2-408.8 ng/mL (r2 = 0.9995) was obtained. Satisfactory intra-day and inter-day precisions were achieved with RSDs less than 9.5 % and the average recovery factors were in the range of 99.1-106.2 %. The method was used to determine the plasma concentration–time profiles for AUR after oral doses of 50, 100 and 200 mg/kg in dogs. A nonlinear pharmacokinetics was found in dogs at doses from 50 to 200 mg/kg. No significant accumulation of AUR in dogs following multiple doses was observed. es
dc.format.extent p. 251-256 es
dc.language en es
dc.title An HPLC Method for the Determination of Auraptene in Dog Plasma: Application to Pharmacokinetic Study es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_12.pdf es
sedici.identifier.issn 0326-2383 es
sedici.creator.person Li, Ming es
sedici.creator.person Yuan, Jinbin es
sedici.creator.person Chen, Heifang es
sedici.creator.person Yang, Wuliang es
sedici.creator.person Luo, Xiaoquan es
sedici.creator.person Liu, Yingin es
sedici.creator.person Zhang, Yu es
sedici.subject.materias Farmacia es
sedici.subject.decs Cromatografía Liquida es
sedici.subject.decs Cromatografía es
sedici.subject.decs Técnicas de Química Analítica es
sedici.subject.keyword auraptene; pharmacokinetics; HPLC; dog plasma es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Latin American Journal of Pharmacy
sedici.relation.journalVolumeAndIssue vol. 31, no. 02


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