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dc.date.accessioned | 2012-05-16T19:40:05Z | |
dc.date.available | 2012-05-16T19:40:05Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/18126 | |
dc.description.abstract | The aim of this study was to determine the kinetic behaviour and the safety of cefepime administered to rabbits. For this, rabbits (n = 29) were used and distributed in Groups 1 (G1), 2 (G2) and Control (CG). Animals from G1 (n = 21) received a monodose of cefepime intravenously, (20 mg/kg weight) and, after this, blood samples were collected, controlling the time. Rabbits from Group G2 (n = 4) received multidoses of cefepime (20 mg/kg weight, intravenously), and blood and urine samples were taken in order to analyse them. Animals from Groups G2 and CG were controlled electrocardiographically (ECG) throughout the treatment. Rabbits from Group CG (n = 4) were evaluated and samples were obtained in the same way and within the same time periods as G2. The concentration-time curves of cefepime were determined using a biological method, and it was analysed through a non-compartmental model. The pharmacokinetic results (Mean ± S.D.) were: t½ = 1.6 ± 0.4 h; AUC = 212.1 ± 82.1 μg/mL.h; AUMC = 387.4 ± 132.2 μg/mL.h; Vss = 216.7 ± 63.4 mL/kg; CL = 99.7 ± 19.4 mL/kg y TMR = 2.0 ± 0.4 h. The cefepime administered to rabbits in therapeutic doses did not produce any biochemical, electrocardiographic or renal modification. | en |
dc.format.extent | 287-291 | es |
dc.language | en | es |
dc.subject | Fenómenos Bioquímicos | es |
dc.subject | cefepime; pharmacokinetics; rabbits; safety | es |
dc.subject | Farmacocinética | es |
dc.title | Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits | en |
dc.type | Articulo | es |
sedici.identifier.uri | http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_17.pdf | es |
sedici.identifier.issn | 0326-2383 | es |
sedici.creator.person | Rule, Roberto | es |
sedici.creator.person | Petinelli, A. | es |
sedici.creator.person | Cordiviola, Carlos Ángel | es |
sedici.creator.person | Prozzi, Guillermo Rafael | es |
sedici.creator.person | Farina, Osvaldo Hugo | es |
sedici.creator.person | Villagra, Sergio | es |
sedici.subject.materias | Farmacia | es |
sedici.description.fulltext | false | es |
mods.originInfo.place | Colegio de Farmacéuticos de la Provincia de Buenos Aires | es |
sedici.subtype | Articulo | es |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Latin American Journal of Pharmacy | |
sedici.relation.journalVolumeAndIssue | vol. 31, no. 02 |