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dc.date.accessioned 2012-05-16T19:40:05Z
dc.date.available 2012-05-16T19:40:05Z
dc.date.issued 2012
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/18126
dc.description.abstract The aim of this study was to determine the kinetic behaviour and the safety of cefepime administered to rabbits. For this, rabbits (n = 29) were used and distributed in Groups 1 (G1), 2 (G2) and Control (CG). Animals from G1 (n = 21) received a monodose of cefepime intravenously, (20 mg/kg weight) and, after this, blood samples were collected, controlling the time. Rabbits from Group G2 (n = 4) received multidoses of cefepime (20 mg/kg weight, intravenously), and blood and urine samples were taken in order to analyse them. Animals from Groups G2 and CG were controlled electrocardiographically (ECG) throughout the treatment. Rabbits from Group CG (n = 4) were evaluated and samples were obtained in the same way and within the same time periods as G2. The concentration-time curves of cefepime were determined using a biological method, and it was analysed through a non-compartmental model. The pharmacokinetic results (Mean ± S.D.) were: t½ = 1.6 ± 0.4 h; AUC = 212.1 ± 82.1 μg/mL.h; AUMC = 387.4 ± 132.2 μg/mL.h; Vss = 216.7 ± 63.4 mL/kg; CL = 99.7 ± 19.4 mL/kg y TMR = 2.0 ± 0.4 h. The cefepime administered to rabbits in therapeutic doses did not produce any biochemical, electrocardiographic or renal modification. en
dc.format.extent 287-291 es
dc.language en es
dc.subject Fenómenos Bioquímicos es
dc.subject cefepime; pharmacokinetics; rabbits; safety es
dc.subject Farmacocinética es
dc.title Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits en
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_17.pdf es
sedici.identifier.issn 0326-2383 es
sedici.creator.person Rule, Roberto es
sedici.creator.person Petinelli, A. es
sedici.creator.person Cordiviola, Carlos Ángel es
sedici.creator.person Prozzi, Guillermo Rafael es
sedici.creator.person Farina, Osvaldo Hugo es
sedici.creator.person Villagra, Sergio es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Latin American Journal of Pharmacy
sedici.relation.journalVolumeAndIssue vol. 31, no. 02


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