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dc.date.accessioned 2012-06-13T20:21:23Z
dc.date.available 2012-06-13T20:21:23Z
dc.date.issued 2012
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/18255
dc.description.abstract The metabolism and excretion profile in rats were investigated after a single dose of daphnoretin. Metabolites of daphnoretin in rats were characterized by HPLC-MS n analysis. A HPLC-UV method was developed to determine the concentration of daphnoretin in rat urine, feces and bile. Daphnoretin was biotransformed via conjunctive and oxidative pathways to three detected metabolites. The structures of these metabolites were tentatively identified. The cumulative excretion percentage of daphnoretin in urine, feces and bile of rats was 0.13, 52.7, and 0.018 %, respectively. All the metabolites and excretion data are reported for the first time. es
dc.format.extent 399-406 es
dc.language en es
dc.subject daphnoretin; excretion; metabolites identification; oral administration es
dc.subject Metabolismo es
dc.subject Farmacología es
dc.title Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_8.pdf es
sedici.identifier.issn 0326-2383 es
sedici.creator.person Sun, Lixin es
sedici.creator.person Sun, Changshan es
sedici.creator.person Guo, Junyang es
sedici.creator.person Yang, Wengen es
sedici.creator.person Jia, Yurong es
sedici.creator.person Tong, Lijin es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Latin American Journal of Pharmacy
sedici.relation.journalVolumeAndIssue vol. 31, no. 3


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