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dc.date.accessioned 2012-08-28T15:49:27Z
dc.date.available 2012-08-28T15:49:27Z
dc.date.issued 2012
dc.identifier.uri http://hdl.handle.net/10915/20230
dc.description.abstract The development of novel HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating novel structures of increased potency. Based on the bioisosterism principle, two novel 2-(5-(naphthalen-1-yl)-1,2,3-thiadiazol-4-ylthio)-N-acetamides derivatives have been designed, synthesized and evaluated for their anti-HIV activities in MT-4 cells. The results indicate that these compounds show good activities against HIV-1. Especially, compound 9B (EC50 = 0.019 μM) was more effective than the reference drugs nevirapine and delavirdine. en
dc.format.extent p. 751-755 es
dc.language en es
dc.title Synthesis and Anti-HIV Activity Evaluation of 2-(5-(Naphthalen-1-yl)-1,2,3-thiadiazol-4-ylthio)-N-acetamides Derivatives en
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_2_3.pdf es
sedici.identifier.issn 0326-2383
sedici.creator.person Jiang, Xiaofei es
sedici.creator.person Zhan, Peng es
sedici.creator.person Liu, Xinyong es
sedici.creator.person Clercq, Erik de es
sedici.subject.materias Farmacia es
sedici.subject.decs Agentes Antivirales es
sedici.subject.decs Tiadiazoles es
sedici.subject.keyword Antiviral activity en
sedici.subject.keyword HIV-1 en
sedici.subject.keyword Synthesis en
sedici.subject.keyword Thiadiazole en
sedici.subject.keyword Thioacetanilides en
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 31, no. 5 es

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