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dc.date.accessioned 2014-05-19T18:38:40Z
dc.date.available 2014-05-19T18:38:40Z
dc.date.issued 2005-01
dc.identifier.uri http://hdl.handle.net/10915/35631
dc.description.abstract The aim of this study was to describe the bone changes observed after a daily oral administration of the calcinogenic plant Solanum malacoxylon (syn. S. glaucophyllum) (Sm) during 9 days. The Sm-poisoned rabbits had an increase of bone resorption in the endosteal surface of the cortical zone and an also in the surface covered by osteoblasts of the primary and secondary spongiosa of the trabecular bone compartment. Moreover, the epiphyseal growth plates in long bones appeared narrower than in the control rabbits, with reduction of the proliferative and hyperthrophic chondrocyte zones. The electron microscopic study revealed a significant decrease of proteoglycans in the hyperthrophic chondrocyte zone evidenced by a significant reduction of rutenium red positive granules in the poisoned rabbit. Altogether, these data suggest that cell differentiation may play a pivotal role in the pathogenesis of Sm-induced bone lesions. en
dc.format.extent p. 34-38 es
dc.language en es
dc.title Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits en
dc.type Articulo es
sedici.identifier.uri http://www.scielo.br/pdf/pvb/v25n1/23871.pdf es
sedici.identifier.other eid:2-s2.0-20044394214
sedici.identifier.issn 0100-736X es
sedici.creator.person Aguirre, José Ignacio es
sedici.creator.person Gomar, María Soledad es
sedici.creator.person Igal, Silvio es
sedici.creator.person Quiroga, María Alejandra es
sedici.creator.person Portiansky, Enrique Leo es
sedici.creator.person Gimeno, Eduardo Juan es
sedici.subject.materias Ciencias Veterinarias es
sedici.subject.other proteoglycan en
sedici.subject.other ruthenium red en
sedici.subject.other bone growth en
sedici.subject.other carcinogenicity en
sedici.subject.other epiphysis en
sedici.subject.other pathogenesis en
sedici.subject.other trabecular bone en
sedici.subject.other Oryctolagus cuniculus en
sedici.subject.keyword bone tissue en
sedici.subject.keyword calcinogenic plant en
sedici.subject.keyword growth plate en
sedici.subject.keyword rabbit en
sedici.subject.keyword S. Glaucophyllum en
sedici.subject.keyword Solanum malacoxylon en
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Veterinarias es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Pesquisa Veterinária Brasileira es
sedici.relation.journalVolumeAndIssue vol. 25, no. 1 es


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Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)