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dc.date.accessioned 2018-05-24T14:38:14Z
dc.date.available 2018-05-24T14:38:14Z
dc.date.issued 2012
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/67015
dc.description.abstract The intake of a fructose-rich diet (FRD) in the normal female rat induces features similar to those observed in the human metabolic syndrome phenotype. We studied the impact of FRD administration to mothers on pregnancy outcome. On gestational day (Gd) zero rats were assigned to either group: ad libitum drinking tap water alone (normal diet, ND) or containing fructose (10% w/vol; FRD) through pregnancy; all rats were fed a Purina chow diet ad libitum ND and FRD rats were daily cotreated or not with metformin (60 mg/Kg/day oral; ND + MF and FRD + MF) and submitted to a high glucose load test on Gd 14. Additionally, placentas from different groups were studied on Gd 20. Data indicated that: (1) although FRD rats well tolerated glucose overload, their circulating levels of insulin were significantly higher than in ND rats; (2) the mesometrial triangle blood vessel area was significantly lower in placentas from FRD than ND dams; (3) the detrimental effects of FRD administration to mothers were ameliorated by metformin cotreatment. Our study suggests that excessive intake of fructose during pregnancy enhanced the risk for developing gestational diabetes and subsequent preeclampsia, and that metformin prevented the poor pregnancy outcome induced by FRD. en
dc.language en es
dc.subject Fructosa es
dc.subject Insulina es
dc.title Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet en
dc.type Articulo es
sedici.identifier.uri https://www.hindawi.com/journals/isrn/2012/757913/ es
sedici.identifier.other https://doi.org/10.5402/2012/757913
sedici.creator.person Alzamendi, Ana es
sedici.creator.person Del Zotto, Héctor Herminio es
sedici.creator.person Castrogiovanni, Daniel es
sedici.creator.person Romero, José es
sedici.creator.person Giovambattista, Andrés es
sedici.creator.person Spinedi, Eduardo es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Instituto Multidisciplinario de Biología Celular es
mods.originInfo.place Centro de Endocrinología Experimental y Aplicada es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle ISRN Endocrinology es
sedici.relation.journalVolumeAndIssue vol. 2012, art. ID 757913 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International (CC BY 4.0)