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dc.date.accessioned 2018-06-13T17:51:35Z
dc.date.available 2018-06-13T17:51:35Z
dc.date.issued 1994
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/67403
dc.description.abstract The direct effect of different vanadium compounds upon alkaline phosphatase (ALP) activity was investigated~ Vanadate and vanadyl inhibited both the soluble and particulate ALP activity from UMR.106 cells and front bovine intestinal ALP. We have also shown the inhibition of ALP activity in the soluble fraction of osteoblasts by peroxo and hydroperoxo vanadium compounds. ALP activity in the particulate fraction was not inhibited by these species; nor was the bovine intestinal ALP. Using inhibitors of Tyr-phosphatase (PTPases), the soluble ALP was partially characterized as a PTPase. The major activity in the particulate fraction represents the bone-specific ALPactivity. This study demonstrates that different forms of vanadium are direct inhibitors of ALP activity. This effect is dependent on the enzymatic activity investigated and on the origin of the ALP. en
dc.format.extent 331-339 es
dc.language en es
dc.subject vanadium, alkaline phosphatase, tyrosine-phosphatase, osteoblast cells, bone cells, inhibitory effects en
dc.subject Vanadio es
dc.subject Fosfatasa Alcalina es
dc.title Vanadium Compounds en
dc.type Articulo es
sedici.identifier.uri https://link.springer.com/article/10.1007%2FBF02917433 es
sedici.identifier.other http://hdl.handle.net/11746/4446
sedici.identifier.issn 0163-4984 es
sedici.title.subtitle Their Action on Alkaline Phosphatase Activity en
sedici.creator.person Cortizo, Ana María es
sedici.creator.person Salice, Viviana C. es
sedici.creator.person Etcheverry, Susana B. es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Médicas es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Biological Trace Element Research es
sedici.relation.journalVolumeAndIssue vol. 41 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 4.0 International (CC BY 4.0)