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dc.date.accessioned 2009-06-17T17:04:44Z
dc.date.available 2009-06-17T03:00:00Z
dc.date.issued 2008 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/7700
dc.description.abstract Passiflora alata Curtis is used in Brazilian folk medicine and also by pharmaceutical industry due to its tranquilizing properties. In this work, the central activity of an aqueous (AQ) and an hydroethanolic (HE) leaves extracts were evaluated in elevated plus maze, barbiturate sleeping time, open field and [3H]flunitrazepam binding assays. The only effect presented by AQ (300 mg/kg, p.o.) was on the barbiturate sleeping time, indicating a hypnotic effect. The HE extract (300 and 600 mg/kg, p.o.) also increased the barbiturate sleeping time and reduced the locomotor activity (at 600 mg/kg, p.o.), pointing to a sedative effect. In addition HE showed an anxiolytic-like effect (300 mg/kg, p.o.) in the elevated plus maze test which was blocked by flumazenil (6 mg/kg, i.p.). Nevertheless HE did not displace [3H]flunitrazepam binding to rat brain synaptosomes in concentrations up to 1000 μg/mL. As a conclusion, we showed that the anxiolytic effect of P. alata in mice depends on the dose and solvent used for the extract preparation, and this effect cannot be attributed to the direct activation of the central benzodiazepine site by the chemical constituents of the extract. It is possible that their metabolites or an indirect effect on benzodiazepine- GABAA receptor complex mediate the observed anxiolytic effect. es
dc.format.extent 845-851 es
dc.language en es
dc.subject Extractos de plantas es
dc.subject anxiolytic; Passiflora alata; sedative es
dc.subject Farmacología es
dc.subject Efectos fisiológicos de las drogas es
dc.title Participation of GABA-benzodiazepine receptor complex in the anxiolytic effect of Passiflora alata Curtis (Passifloraceae) es
dc.title.alternative Participation of GABA-benzodiazepine Receptor Complex in the Anxiolytic Effect of Passiflora alata Curtis (Passifloraceae) en
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/trabajos/27/6/LAJOP_27_6_1_7_84873RKMDB.pdf es
sedici.creator.person Provensi, Gustavo es
sedici.creator.person Nöel, François es
sedici.creator.person Lopes, Daniela V.S. es
sedici.creator.person Fenner, Raquel es
sedici.creator.person Betti, Andresa H. es
sedici.creator.person Costa, Fernanda de es
sedici.creator.person Morais, Everton C. es
sedici.creator.person Grosmann, Grace es
sedici.creator.person Rates, Stela M.K. es
sedici.subject.materias Farmacia es
sedici.description.fulltext true es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001186 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 27, no. 6 es

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