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dc.date.accessioned 2009-06-22T11:49:30Z
dc.date.available 2009-06-22T03:00:00Z
dc.date.issued 2009 es
dc.identifier.uri http://hdl.handle.net/10915/7735
dc.description.abstract Insulin resistance is associated with a defect in protein tyrosine phosphorylation in the insulin signal transduction cascade. PTPase enzyme dephosphorylates the active form of insulin receptor and thus attenuates its tyrosine kinase activity, therefore the need of a potent PTPase inhibitor is the reason for the present Quantitative Structure-Activity relationship (QSAR) was performed. QSAR has been established on a series of compounds of novel benzofuran biphenyl/naphthalene's analogs using SYSTAT (Version 7.0) software, for their protein tyrosine phosphatase (PTPase-1B) inhibitor activity, in order to understand the essential structural requirement for binding with the receptor. Among several 2D QSAR models, one for a series was selected on the basis of high correlation coefficient, least standard deviation, & high value of significance for maximum no. of subject was considered. The interpreted data signify the essentiality of hydrophobic character at X in the designing of the new PTPase -1B inhibitors of naphthalene analogs but not in biphenyl derivatives as shown in earlier result. es
dc.format.extent p. 112-115 es
dc.language en es
dc.title 2-D QSAR analysis of benzofuran biphenyl/naphthalenes as potent protein tyrosine phosphatase-1B inhibitors es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_2_5_9FB0059C44.pdf es
sedici.creator.person Kaushik, Darpan es
sedici.subject.materias Farmacia es
sedici.subject.descriptores Medicamento es
sedici.subject.descriptores Composición de medicamentos es
sedici.subject.descriptores Insulina es
sedici.subject.keyword benzofuran biphenyl/naphthalenes; PTPase-1B Inhibitor; QSAR es
sedici.description.fulltext true es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001221 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 28, no. 1 es


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