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dc.date.accessioned 2009-06-23T12:41:42Z
dc.date.available 2009-06-23T03:00:00Z
dc.date.issued 2009 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/7748
dc.description.abstract Phenobarbital and carbamazepine are antiepileptic drugs that act at the nervous central system by different mechanisms of action. In this work we investigated the pharmacological effects of these drugs on mouse phrenic nerve-diaphragm preparations through the myographic technique. Carbamazepine (0.105, 1.05, 2.1 and 4.2 mM, n = 8, 6, 6 and 6, respectively), induced a dose-dependent neuromuscular blockade, under indirect or direct muscle stimulation and the neurotransmission was reestablished after washing. Conversely, phenobarbital caused an unexpected facilitatory effect, under several formulations, such as the acid-extracted commercial tablets (1.05, 2.1 and 4.2 mM, n = 7, 6 and 7, respectively), commercial phenobarbital solution (4.2 mM, n = 7) or its correspondent pure active ingredient (4.2 and 2.1 mM, n = 6 each). Only at a higher concentration the acid-extracted phenobarbital performed a neuromuscular blockade (8.4 mM, n = 10). The different responses between carbamazepine (paralysis) and phenobarbital (facilitatory effect) evidentiated a new effect for phenobarbital until now concealed at the neuromuscular junction and may involve the glutamatergic regulation, since its role as an acetylcholine co-transmitter in motoneurons was already established. es
dc.format.extent 211-218 es
dc.language en es
dc.subject Medicamento es
dc.subject antiepileptic drugs; neuromuscular junction; pharmacologic actions es
dc.subject Sistema Nervioso Central es
dc.title Phenobarbital pharmacological findings on the nerve-muscle basis es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_7_0F5VI3J8T0.pdf es
sedici.creator.person Rubem-Mauro, Leandro es
sedici.creator.person Rocha Jr, Dimas S. es
sedici.creator.person Barcelos, Caroline C. es
sedici.creator.person Costa Varca, Gustavo H. es
sedici.creator.person Andréo Filho, Newton es
sedici.creator.person Barberato Fihlo, Silvio es
sedici.creator.person Oshima-Franco, Yoko es
sedici.creator.person Vila, Marta M. D. C. es
sedici.subject.materias Farmacia es
sedici.description.fulltext true es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001234 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 28, no. 2 es

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