Diphenylpropanoids from quisqualis indica linn. and their anti-staphylococcal activity

Abstract

Four diphenylpropanoids- 1-(4-hydroxy-3-methoxyphenyl)-2-(4-allyl-2,6-dimethoxyphenoxy)propan-1-ol (1), 1-(3,4-dimethoxyphenyl)-2-(4-allyl-2,6-dimethoxyphenoxy)propan-1-ol (2), 1-(3,4- dime thoxyphenyl ) -2- (4-al lyl -2,6-dime thoxyphenoxy)propan-1-ylac e tat e (3) and 1- (4-hydroxy-3,5- dimethoxyphenyl)-2-(4-allyl-2,6-dimethoxyphenoxy) propan-1-ol (4) were isolated from the chloroform soluble fraction of a methanol extract of Quisqualis indica. The structures of these compounds were established unambiguously by MS and a series of 1D and 2D-NMR analyses. All compounds were tested for their anti-staphylococcal activity against a total of five multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus strains and the minimum inhibitory concentrations (MICs) were in the range of 128-256 μg/ml