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dc.date.accessioned 2019-07-04T16:26:33Z
dc.date.available 2019-07-04T16:26:33Z
dc.date.issued 2016
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/77690
dc.description.abstract Adipose tissue (AT) expansion is the result of two processes: hyperplasia and hypertrophy; and both, directly or indirectly, depend on the adipogenic potential of adipocyte precursor cells (APCs). Glucocorticoids (GCs) have a potent stimulatory effect on terminal adipogenesis; while their effects on early stages of adipogenesis are largely unknown. In the present work, we study, in a model of high GC levels, the adipogenic potential of APCs from retroperitoneal AT (RPAT) and its relationship with RPAT mass expansion. We employed a model of hyper-adiposity (30- and 60-day-old rats) due to high endogenous GC levels induced by neonatal treatment with L-monosodium glutamate (MSG).We found that the RPAT APCs from 30-day-old MSG rats showed an increased adipogenic capacity, depending on the APCs’ competency, but not in their number. Analyses of RPAT adipocyte diameter revealed an increase in cell size, regardless of the rat age, indicating the prevalence of a hypertrophic process. Moreover, functional RPAT alterations worsened in 60-day-old rats, suggesting that the hyperplastic AT expansion found in 30-day-old animals might have a protective role. We conclude that GCs chronic excess affects APCs’ adipogenic capacity, modifying their competency. This change would modulate the hyperplastic/hypertrophic balance determining healthy or unhealthy RPAT expansion and, therefore, its functionality. en
dc.language en es
dc.subject retroperitoneal adipose tissue; adipogenesis; stromal vascular fraction cells; cell determination; adipogenic competency en
dc.subject Tejido Adiposo es
dc.title Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model en
dc.type Articulo es
sedici.identifier.other https://doi.org/10.3390/nu8070410
sedici.identifier.other http://hdl.handle.net/11746/7024
sedici.creator.person Zubiría, María Guillermina es
sedici.creator.person Alzamendi, Ana es
sedici.creator.person Moreno, Griselda es
sedici.creator.person Portales, Andrea Estefanía es
sedici.creator.person Castrogiovanni, Daniel Cayetano es
sedici.creator.person Spinedi, Eduardo Julio es
sedici.creator.person Giovambattista, Andrés es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Médicas es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Nutrients es
sedici.relation.journalVolumeAndIssue vol. 8, no. 7 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International (CC BY 4.0)