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dc.date.accessioned 2009-08-11T15:54:12Z
dc.date.available 2009-08-11T03:00:00Z
dc.date.issued 2009 es
dc.identifier.uri http://hdl.handle.net/10915/7779
dc.description.abstract A double-center, open-label, two-way crossover study was conducted in 24 healthy volunteers to assess the bioequivalence of a combined lamivudine/zidovudine tablet related to a reference and test drug products. The volunteers were randomly assigned to receive one lamivudine/zidovudine combination tablet of reference or test product with 7-days washout period between. Blood samples were collected up to 36 h post dose. Pharmacokinetic parameters were estimated. Drug products were bioequivalent if 90% confidence intervals for the ratio of least squares (CI 90%) means are under plasma concentration-time curve (AUC0-τ ) and absorption rate (Cmax) fell within 80 to 125% for log-transformed parameters. Test and reference products present data of AUC0-τ , Cmax referents to lamivudine and data of ASC∞ referents to zidovudine, in agreement of these limits. The result of Cmax (CI 90%) to zidovudine was: 116% (90- 141%), it has confirm that the zidovudine has high individual variability of absorption. es
dc.format.extent p. 433-437 es
dc.language en es
dc.title Bioequivalence test applied to a new lamivudine/zidovudine combined formulation tablet es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_16_V0B1X2XE46.pdf es
sedici.creator.person Souza, Jacqueline de es
sedici.creator.person Kano, Eunice K. es
sedici.creator.person Koono, Eunice E. es
sedici.creator.person Schramm, Simone G. es
sedici.creator.person Porta, Valentina es
sedici.creator.person Storpiritis, Sílvia es
sedici.subject.materias Farmacia es
sedici.subject.descriptores Farmacología es
sedici.subject.descriptores Farmacocinética es
sedici.subject.keyword lamivudine; zidovudine; bioequivalencia es
sedici.subject.keyword lamivudine; zidovudine; bioequivalence en
sedici.description.fulltext true es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici2003.identifier ARG-FARM-ART-0000001266 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 28, no. 3 es

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