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dc.date.accessioned 2009-08-12T12:21:59Z
dc.date.available 2009-08-12T03:00:00Z
dc.date.issued 2009 es
dc.identifier.uri http://hdl.handle.net/10915/7780
dc.description.abstract The purpose of the present investigation was to evaluate 6-O-palmitoyl ascorbic acid (ASC16) and 6-O-lauril ascorbic acid (ASC12) for their capacity to promote permeation of Ibuprofen (IBU) through hairless mouse skin in vitro. The permeation of Arfen® (IBU 10% P/P, commercial product), IBU solution (0.85% P/P, pH 7.4, 66.7 mM phosphate buffer: Isopropyl alcohol; 80:20) and IBU (0.85% P/P) vehiculized in ASCn coagels (5% w/v) were measured and comparatively analyzed. Although IBU release from the formulation was faster in the case of Arfen® in comparison to ASCn coagel, the permeation of IBU was significantly increased when the drug was vehiculized in these systems, being ASC12 the most effective as enhancer. This result demonstrated the potential usefulness of the lamellar liquid crystalline system obtained from ASCn auto-aggregation for topical administration of drugs. es
dc.format.extent p. 438-442 es
dc.language en es
dc.title Effect of different coagels of 6-O-ascorbic acid alkanoates on permeation of Ibuprofen through hairless mouse skin es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_17_9C8955F2PI.pdf es
sedici.creator.person Saino, Verónica es
sedici.creator.person Chetoni, Patrizia es
sedici.creator.person Palma, Santiago D. es
sedici.creator.person Allemandi, Daniel A. es
sedici.subject.materias Farmacia es
sedici.subject.descriptores Medicamento es
sedici.subject.descriptores Farmacología es
sedici.subject.descriptores Agentes Antiinflamatorios es
sedici.subject.descriptores Evaluación de drogas es
sedici.subject.keyword ibuprofen; lquid crystals; skin permeation es
sedici.description.fulltext true es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici2003.identifier ARG-FARM-ART-0000001267 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 28, no. 3 es


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