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dc.date.accessioned 2009-09-30T13:40:08Z
dc.date.available 2009-09-30T03:00:00Z
dc.date.issued 2009
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/7804
dc.description.abstract The chloroform extract of Cladonia substellata Vainio was assayed against larvae of Aedes aegypti, the mosquito vector of Dengue fever and Artemia salina. The extract was tested at concentrations ranging from 1 to 15 ppm in an aqueous medium for 24 h. LC50 and LC90 were evaluated. Since the chloroform extract proved to be lethal for third to fourth instar larvae, downstream processing was undertaken to purify the active agents in the extract. The major compound in the chloroform extract was purified by crystallization followed by column chromatography to yield yellow crystals. Furthermore, usnic acid (UA) was evaluated for its larvicidal potential. The major compound in the chloroform extract, UA, exhibited LC50 of 6.6 ppm (6.1 to 7.0 ppm). Therefore, UA is most likely the active principle in C. substellata. UA showed to be toxic to A. salina, a reference organism in assays to evaluate the potential toxicity hazard to invertebrates in ecosystems. es
dc.format.extent 580-584 es
dc.language en es
dc.subject Aedes aegypti; Artemia salina; Cladonia substellata; larvicidal activity; usnic acid es
dc.subject Plantas medicinales es
dc.subject Extractos de plantas es
dc.title Larvicidal activity of Cladonia substellata extract and usnic acid against Aedes aegypti and Artemia salina es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/trabajos/28/4/LAJOP_28_4_2_1_OAQ22XY027.pdf es
sedici.creator.person Bomfim, Rangel R. es
sedici.creator.person Araújo, Adriano A. S. es
sedici.creator.person Cuadros-Orellana, Sara es
sedici.creator.person Melo, Marcélia G.D. es
sedici.creator.person Quintans Júnior, Lucindo José es
sedici.creator.person Cavalcanti, Sócrates C.H. es
sedici.subject.materias Farmacia es
sedici.description.fulltext true es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001290 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 28, no. 4 es


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