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dc.date.accessioned 2009-12-01T14:30:18Z
dc.date.available 2009-12-01T03:00:00Z
dc.date.issued 2009 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/7831
dc.description.abstract The present study aims at developing synthesized (PVA-co-PAA)/NaCl normal hydrogel(H), hydrogel microspheres(HM) and comparing the antihypertensive activity of Diltiazem hydrochloride(DL) from two formulations. The hydrogel microspheres were crosslinked by using glutaraldehyde-saturated toluene. The hydrogel showed more swelling in simulated intestinal fluid (SIF). (PVA-co-PAA)/NaCl HM formulation A1 showed comparatively higher entrapment (79%) and better control over DL release. In normotensive rats, HM formulation A1 found more effectively in reducing blood pressure to 40.1%. The experimental results demonstrated that (PVA-co-PAA)/NaCl HM had the greater potential than normal hydrogel to be used as a drug carrier. es
dc.format.extent 747-755 es
dc.language en es
dc.subject Farmacología es
dc.subject drug delivery; hydrogel microspheres; normal hydrogel; stability; swelling es
dc.subject Medicamentos es
dc.title Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_16_M7IJPD4ANB.pdf es
sedici.creator.person Ray, Debajyoti es
sedici.creator.person Mohanta, Guru P. es
sedici.creator.person Gils, P. Sunny es
sedici.creator.person Manavalan, R. es
sedici.creator.person Sahoo, Prafulla K. es
sedici.subject.materias Farmacia es
sedici.description.fulltext true es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001318 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 28, no. 5 es

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