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dc.date.accessioned 2010-02-01T12:28:13Z
dc.date.available 2010-02-01T03:00:00Z
dc.date.issued 2009 es
dc.identifier.uri http://hdl.handle.net/10915/7840
dc.description.abstract The present study investigated the antinociceptive and antiinflammatory activities of the ethanolic extract of Pouteria ramiflora (EEPr) roots, commonly known in Brazil as "curiola". The EEPr (50 or 100 mg/kg) produced inhibition of abdominal constrictions in mice and increased the reaction time in the hotplate test. The EEPr inhibited the inflammatory process induced by carrageenan in the rat air pouch model. When the rats were treated with 50 mg/kg of EEPr, the number of inflammatory cells harvested from the air pouch, nitric oxide metabolites levels and adenosine deaminase activity decreased by 65%, 77% and 68%, respectively. When they were treated with 100 mg/kg of EEPr, the inhibition was higher (81%, 89% and 95%) for the same analyzed parameters. The results of the experiments performed in the present study exhibit pronounced antinociception and also indicate that EEPr exerts antiinflammatory activity by interfering with the lymphocyte proliferation and NO production. es
dc.format.extent p. 812-818 es
dc.language en es
dc.title Antinociceptive and antiinflammatory properties of the ethanolic extract of pouteria ramiflora roots es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_2_161P10Z8KJ.pdf es
sedici.creator.person Fontes Júnior, Enéas A. es
sedici.creator.person Souza, Pergentino J. C. es
sedici.creator.person Nascimento, José L. M. do es
sedici.creator.person Santos, Setsuko N. es
sedici.creator.person Espindola, Laila S. es
sedici.creator.person Ferreira, Vania M. M. es
sedici.subject.materias Farmacia es
sedici.subject.descriptores Farmacología es
sedici.subject.descriptores Extractos de plantas es
sedici.subject.keyword antiinflammation; antinociception; hotplate test; writhing test es
sedici.description.fulltext true es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001327 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 28, no. 6 es


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