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dc.date.accessioned 2010-07-01T15:15:25Z
dc.date.available 2010-07-01T03:00:00Z
dc.date.issued 2010 es
dc.identifier.uri http://hdl.handle.net/10915/7947
dc.description.abstract The aim of this study was to formulate ethyl cellulose (EC) microparticles for sustained release of nimesulide and study the effect of processing variables, drug to polymer ratio and also study the drug polymer compatibility. The microparticles were prepared by coacervation (temperature change) technique. Physical properties, such as particle size, entrapment efficiency, release pattern and morphological characteristics were investigated by in vitro dissolution, SEM, FTIR, XRD, DSC and TGA in order to optimize the formulation of the microparticles. With the increase of polymer concentration there was an increase in size and drug entrapment efficiency of microparticles. There was a decrease in size and nonlinear change in entrapment efficiency with the increase of stirring speed and time. The release of drug from microparticles was anomalous diffusion. It was confirmed that there is no strong chemical interaction between drug and polymer except the change in crystal habit and polymorphism. Ethyl cellulose microparticles containing nimesulide are suitable for controlled release devising. es
dc.format.extent p. 554-561 es
dc.language en es
dc.title Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_10.pdf es
sedici.creator.person Khan, Shujaat A. es
sedici.creator.person Ahmad, Mahmood es
sedici.creator.person Aamir, Muhammad N. es
sedici.creator.person Murtaza, Ghulam es
sedici.creator.person Rasool, Fatima es
sedici.creator.person Akhtar, Muhammad es
sedici.subject.materias Farmacia es
sedici.subject.descriptores Farmacología es
sedici.subject.descriptores Medicamentos es
sedici.subject.descriptores Polímeros es
sedici.subject.keyword ethyl cellulose; microparticles; nimesulide; polymer ratio; processing variables es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001434 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 4 es


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