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dc.date.accessioned 2010-07-01T15:26:47Z
dc.date.available 2010-07-01T03:00:00Z
dc.date.issued 2010 es
dc.identifier.uri http://hdl.handle.net/10915/7948
dc.description.abstract The present investigation concerns the development of a floating matrix tablet, which after oral administration prolong the gastric residence time and increases bioavailability of drugs, which are predominantly absorbed from gastric region .With this aim, floating dosage form containing baclofen as drug, and different grades of HPMC as release retarding polymer was prepared. Sodium bicarbonate and citric acid were used as gas generating agents. Some factors were investigated concerning the effect of release retarding polymer on drug release behaviors like t50% and t90%. A 32 factorial design was applied to optimize the drug release profile. The amounts of HPMC K4M(X1) and HPMC K100M (X2) were selected as independent variables. The time required for 50% (t50%) and 90% (t90%) drug dissolution were selected as dependent variables. The results of full factorial design indicates that moderate amount of both the release retardant polymer, controlled the release behavior. It can be concluded from release kinetic models that the release followed Higuchi model, as the correlation coefficient (R2 value) was high in all the evaluated models. The release mechanism followed non-fickian diffusion as the release exponent (n-value) was >0.5 in all the optimized formulations. es
dc.format.extent p. 562-567 es
dc.language en es
dc.title Development, evaluation and optimization of baclofen oral floating tablet es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_11.pdf es
sedici.creator.person Singh, Akhilesh V. es
sedici.creator.person Pandey, Rishabh D. es
sedici.creator.person Nath, Lila K. es
sedici.creator.person Das, Anudwipa es
sedici.subject.materias Farmacia es
sedici.subject.descriptores Farmacología es
sedici.subject.descriptores Medicamentos es
sedici.subject.descriptores Composición de medicamentos es
sedici.subject.keyword baclofen; floating tablets; optimization; sustained release es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001435 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 4 es


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