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dc.date.accessioned 2010-08-23T16:20:30Z
dc.date.available 2010-08-23T03:00:00Z
dc.date.issued 2010
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/7974
dc.description.abstract The aim of the present study was to evaluate the antimicrobial and cytotoxic activity of the ethanolic extract of S. cumini according to the Clinical and Laboratory Standards Institute reference method (with modifications), determining the minimal inhibitory and lethal concentration. Activity against Gram-positive (Staphylococcus aureus and S. epidermidis), Gram-negative (Pseudomonas aeruginosa) and yeast of Candida sp and Cryptococcus neoformans was evaluated. The effects of the fruit extract were examined in hamster cells ovaries in concentrations ranging from 1250.0 a 4.9 μg/ml, measuring the r educ t ion of the t e t razol ium sal t 3- (4,5-dime thyl thiazol -2-yl ) -5- (3- carboxyme thoxyphenyl ) -2- (4- sulphophenyl)-2H-tetrazolium. The extract showed both bactericidal and fungicidal activity among the various microorganisms tested and the MIC ranging from 7.8 to 250 μg/ml. The MIC, MBC and MFC should values that were similar for all the microorganisms. Cytotoxicity index of the dried extract corresponded to the concentration of 400 μg/ml. The extract could potentially be used in topical antimicrobial products. Thus, the activity of extract was potent to bacteria and mainly to non-albicans species and C. neoformans. en
dc.format.extent 725-730 es
dc.language en es
dc.subject Farmacología es
dc.subject antibacterial; antifungal; antimicrobial activity; cytotoxic activity; jambolan; minimum inhibitory concentration; minimal lethal concentration; Syzygium cumini es
dc.subject Citotoxicidad es
dc.subject Plantas medicinales es
dc.title Antimicrobial and cytotoxic activity of fruit extract from Syzygium cumini (L.) Skeels en
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_13.pdf es
sedici.creator.person Migliato, Ketylin F. es
sedici.creator.person Mello, João Carlos Palazzo de es
sedici.creator.person Higa, Olga Z. es
sedici.creator.person Rodas, Andrea C. D. es
sedici.creator.person Corrêa, Marcos A. es
sedici.creator.person Mendes Giannini, Maria J.S. es
sedici.creator.person Fusco Almeida, Ana M. es
sedici.creator.person Pizzolitto, Antonio C. es
sedici.creator.person Salgado, Hérida R.N. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001461 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 5 es

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