Upload resources

Upload your works to SEDICI to increase its visibility and improve its impact

 

Show simple item record

dc.date.accessioned 2010-08-24T11:35:10Z
dc.date.available 2010-08-24T03:00:00Z
dc.date.issued 2010 es
dc.identifier.uri http://hdl.handle.net/10915/7975
dc.description.abstract Nimesulide was formulated as novel dual coated microparticles using chitosan (CTN) and ethyl cellulose (EC) as encapsulating materials for its improved delivery to the intestine and to prevent gastric irritation and increase patient compliance. The first coating was applied by chitosan using pH change method followed by second coating of ethyl cellulose using thermal change method. This process was analysed for its capability to produce microparticles of uniform size, good flowability, uniform drug loading and maximum entrapment efficacy and the absence of interaction between drug and process parameters as well as the polymers confirmed by XRD and FTIR analysis. In vitro release study was carried out in simulated gastric fluid (SGF) for first 2 h and simulated intestinal fluid (SIF) for next 6 h. The formulation M7 and M8 that contained chitosan and ethyl cellulose in the concentration of 1:1 and 1:2 (M1:EC) were found to achieve the targets of the present study such as uniform intestinal release of acidic drug and thus improves the patient compliance. es
dc.format.extent p. 731-737 es
dc.language en es
dc.title Dual coated microparticles for intestinal delivery of nimesulide es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_14.pdf es
sedici.creator.person Khan, Shujaat A. es
sedici.creator.person Ahmad, Mahmood es
sedici.creator.person Murtaza, Ghulam es
sedici.creator.person Aamir, Muhammad N. es
sedici.creator.person Akhtar, Naveed es
sedici.subject.materias Farmacia es
sedici.subject.descriptores Medicamentos es
sedici.subject.descriptores Composición de medicamentos es
sedici.subject.descriptores Farmacología es
sedici.subject.keyword chitosan; dual coating; ethyl cellulose; microencapsulation; microparticles; nimesulide es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001462 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 5 es


Files in this item

This item appears in the following Collection(s)