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dc.date.accessioned 2010-08-26T15:43:02Z
dc.date.available 2010-08-26T03:00:00Z
dc.date.issued 2010
dc.identifier.uri http://hdl.handle.net/10915/7994
dc.description.abstract A highly sensitive liquid chromatographic tandem mass spectrometric (LC-MS/MS) method for determination of dextromethorphan in rabbit plasma using triazolam as the internal standard (IS) was developed. Plasma samples were extracted with ethyl acetate and separated on a SB-C18 column with a mobile phase of acetonitrile-water 60:40 (v/v) at a flow of 0.3 mL/min. Detection is carried out by multiple reaction monitoring (MRM) on a ion-trap LC-MS/MS system with an electrospray ionization interface. The lower limit of quantification (LLOQ) was 1 ng/mL. After intravenous administration of a single dose of dextromethorphan 2 mg/kg, the main pharmacokinetic parameters were as follows: AUC0→t 636.13 ± 47.13 (ng/mL·h); CL 2.60 ± 0.24 (L/h), Cmax 874 ± 67.16 (ng/mL), Vz 1.58 ± 0.11 (L/kg), T1/2 2.41 ± 0.35 (h), MRT 1.26 ± 0.08 (h). es
dc.format.extent p. 839-844 es
dc.language en es
dc.title Determination of dextromethorphan in rabbit plasma by LC-MS/MS and its application to pharmacokinetic study es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_2_12.pdf es
sedici.creator.person Hu, Lufeng es
sedici.creator.person Wang, Xianqin es
sedici.creator.person Jiang, Haiyan es
sedici.creator.person Xu, Xuegu es
sedici.creator.person Xu, Ren-ai es
sedici.creator.person Lin, Guanyang es
sedici.subject.materias Farmacia es
sedici.subject.descriptores Medicamentos es
sedici.subject.descriptores Farmacología es
sedici.subject.descriptores Farmacocinética es
sedici.subject.keyword dextromethorphan; LC-MS/MS; determination; rabbit; pharmacokinetic es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001481 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 5 es


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