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Mostrar registro sencillo 2010-08-26T15:43:02Z 2010-08-26T03:00:00Z 2010
dc.description.abstract A highly sensitive liquid chromatographic tandem mass spectrometric (LC-MS/MS) method for determination of dextromethorphan in rabbit plasma using triazolam as the internal standard (IS) was developed. Plasma samples were extracted with ethyl acetate and separated on a SB-C18 column with a mobile phase of acetonitrile-water 60:40 (v/v) at a flow of 0.3 mL/min. Detection is carried out by multiple reaction monitoring (MRM) on a ion-trap LC-MS/MS system with an electrospray ionization interface. The lower limit of quantification (LLOQ) was 1 ng/mL. After intravenous administration of a single dose of dextromethorphan 2 mg/kg, the main pharmacokinetic parameters were as follows: AUC0→t 636.13 ± 47.13 (ng/mL·h); CL 2.60 ± 0.24 (L/h), Cmax 874 ± 67.16 (ng/mL), Vz 1.58 ± 0.11 (L/kg), T1/2 2.41 ± 0.35 (h), MRT 1.26 ± 0.08 (h). es
dc.format.extent p. 839-844 es
dc.language en es
dc.title Determination of dextromethorphan in rabbit plasma by LC-MS/MS and its application to pharmacokinetic study es
dc.type Articulo es
sedici.identifier.uri es
sedici.creator.person Hu, Lufeng es
sedici.creator.person Wang, Xianqin es
sedici.creator.person Jiang, Haiyan es
sedici.creator.person Xu, Xuegu es
sedici.creator.person Xu, Ren-ai es
sedici.creator.person Lin, Guanyang es
sedici.subject.materias Farmacia es
sedici.subject.descriptores Medicamentos es
sedici.subject.descriptores Farmacología es
sedici.subject.descriptores Farmacocinética es
sedici.subject.keyword dextromethorphan; LC-MS/MS; determination; rabbit; pharmacokinetic es
sedici.description.fulltext false es Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001481 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 5 es

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