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dc.date.accessioned 2010-09-23T12:56:58Z
dc.date.available 2010-09-23T03:00:00Z
dc.date.issued 2010 es
dc.identifier.uri http://hdl.handle.net/10915/7998
dc.description.abstract The dissolution behavior of five commercially available brands of sustained release theophylline tablets was studied in phosphate buffer solutions of pH 1.2, 4.5, 5.5, 6.0 and 7.5 at 37 °C using the USP dissolution apparatus II (paddle method). Drug concentration in the samples was determined spectrophotometrically at 272 nm. For predicting the release characteristics of theophylline from selected commercially available tablets the data obtained in the dissolution studies was fitted into various mathematic models defining kinetic parameters of drug release like zero-order rate equation, first-order rate equation, Hixen-crowell cube root law, Higuchi equation and Korsemeyer-Peppas model. Tablets were subjected to weight variation test, hardness, drug content and in vitro release studies. The present study revealed that drug release increases with the increase of pH of the dissolution medium and also varies from brand to brand. Among the five selected brands, B1 and B4 showed better pH dependency and drug release behaviour. It has been suggested that possible reasons for difference in dissolution or drug release behaviour are the difference in the manufacturing techniques and the quantity of hydrophobic excepients used by different manufacturers, which retard the penetration of dissolution medium and ultimately decreases availability of drug in the solution. es
dc.format.extent p. 869-875 es
dc.language en es
dc.title In vitro evaluation of commercially available theophylline sustained release tablets in Pakistan es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_3.pdf es
sedici.creator.person Ranjha, Nazar M. es
sedici.creator.person Mudassir, Jahanzeb es
sedici.creator.person Abbas, Tanveer es
sedici.creator.person Siam, Mohammad A.F. es
sedici.creator.person Hussain, Abid es
sedici.subject.materias Farmacia es
sedici.subject.descriptores Farmacología es
sedici.subject.descriptores In vitro es
sedici.subject.descriptores Medicamentos es
sedici.subject.descriptores Disolución es
sedici.subject.descriptores Espectrofotometría es
sedici.subject.keyword in vitro studies; sustained release; tablets; theophylline es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001485 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 6 es


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