Upload resources

Upload your works to SEDICI to increase its visibility and improve its impact

 

Show simple item record

dc.date.accessioned 2010-09-27T14:05:06Z
dc.date.available 2010-09-27T03:00:00Z
dc.date.issued 2010 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8019
dc.description.abstract The purpose of this study was to attain and characterize ternary complexes of simvastatin, β-cyclodextrin (βCD) and different polymers, and then select those that lead to a greater increase in drug solubility. The complexes were prepared with the co-evaporation method and the polymers used were polyethylene glycol 1500, polyethylene glycol 4000, povidone, copovidone, crospovidone, maltodextrin and hydroxypropyl methyl cellulose. The characterization of complexes was carried out through aqueous solubility, DSC and TG. There was an increase in solubility for all the complexes prepared with βCD and the different polymers, but only when crospovidone and maltodextrin were used was there a significant difference observed between the solubility of the physical mixture and that of the complex. The DSC curves indicate that the non-complexed drug is even in the sample of the complex with higher solubility, thus none of the polymers was able to achieve a total complexation of the drug. es
dc.format.extent 1014-1019 es
dc.language en es
dc.subject cyclodextrin; simvastatin; ternary complex es
dc.subject Farmacología es
dc.subject Medicamentos es
dc.subject Evaluación de drogas es
dc.subject Análisis químico es
dc.title Attainment and characterization of ternary complexes of simvastatin-cyclodextrin-hydrossoluble polymers es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_2_4.pdf es
sedici.creator.person Takahashi, Andrea I. es
sedici.creator.person Ferraz, Humberto G. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001506 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 6 es


Download Files

This item appears in the following Collection(s)