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dc.date.accessioned 2010-11-11T18:48:11Z
dc.date.available 2010-11-11T03:00:00Z
dc.date.issued 2010 es
dc.identifier.uri http://hdl.handle.net/10915/8048
dc.description.abstract Oral administration to rats of Rhizoma Paridis saponins (RPS) from Paris polyphylla var. yunnanensis extracts have been found to show strong anti-tumor activity, but the effective constituents were not known. To detail the effective components in RPS, we investigated the serum pharmacochemistry after oral administration of RPS and detected eight kinds of Paridis saponins in the rat serum. Then we purposefully purified a mixture (PM) from RPS to further research. By comparison of tumor weight, spleen index, antitumor rate and numbers of metastases, PM showed a considerable activity as RPS. In conclusion, the serum pharmacochemistry can help us purposefully to separate and purify RPS and to obtain a potential antitumor agent which may be better than parent drugs. es
dc.format.extent p. 1193-1198 es
dc.language en es
dc.title Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_21.pdf es
sedici.creator.person Man, Shuli es
sedici.creator.person Gao, Wenyuan es
sedici.creator.person Zhang, Yanjun es
sedici.creator.person Ma, Chaoyi es
sedici.creator.person Huang, Lijing es
sedici.creator.person Li, Yiwen es
sedici.creator.person Liu, Changxiao es
sedici.creator.person Huang, Luqi es
sedici.subject.materias Farmacia es
sedici.subject.keyword anti-tumor effect; HPLC-MS; Paris polyphylla; serum pharmacochemistry; steroidal saponin es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001535 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 7 es


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