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dc.date.accessioned 2011-01-06T13:20:21Z
dc.date.available 2011-01-06T03:00:00Z
dc.date.issued 2010 es
dc.identifier.uri http://hdl.handle.net/10915/8082
dc.description.abstract Oxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; however, many questions concerning the mechanism of action of such drugs remain unknown. This work investigated the effect of simvastatin on generation of autoantibodies against oxLDL and development of atherosclerosis in rabbits. The animals were divided into three groups: control, hypercholesterolemic, and hypercholesterolemic simvastatin (3.0 mg simvastatin/ kg body weight). Concentrations of autoantibodies against oxLDL were determined on days 0, 30 and 60 of the experiment and the atherosclerotic lesions were evaluated at the end of the study. Simvastatin reduced intimal proliferation in the thoracic region, prevented arterial calcification and inhibited the generation of autoantibodies against oxLDL. In conclusion, daily administration of simvastatin slows down atherosclerotic lesion development in rabbits with induced hypercholesterolemia and inhibition on generation of autoantibodies against oxLDL contributes to the cardioprotective effect observed. es
dc.format.extent p. 1419-1424 es
dc.language en es
dc.title Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_22.pdf es
sedici.creator.person Cavallini, Daniela C. U. es
sedici.creator.person Abdalla, Dulcinéia S. P. es
sedici.creator.person Pauly-Silveira, Nadiége D. es
sedici.creator.person Rossi, Elizeu A. es
sedici.subject.materias Farmacia es
sedici.subject.keyword atherosclerosis; autoantibodies against oxidized LDL; simvastatin es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001569 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 8 es


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