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dc.date.accessioned | 2011-03-04T15:02:04Z | |
dc.date.available | 2011-03-04T03:00:00Z | |
dc.date.issued | 2011 | es |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/8101 | |
dc.description.abstract | A reversed-phase high-performance liquid chromatographic (RP-HPLC) method for related substances test of seratrodast in bulk drugs has been developed. The separation was achieved on a ZirChrom Kromasil C18 (200 mm×4.6 mm, 5 µm) column thermostated at 30 ºC using acetonitrile-0.05 M pH 3.0 potassium dihydrogen orthophosphate buffer (60:40, v/v) as a mobile phase. Wavelength was set at 267 nm. An external standard method using a dilution of the sample solution as reference was used for the purity test. The method was found to be simple, rapid, specific and sensitive with detection limit of 0.67 ng. A thorough study has been undertaken to identify and characterize an unknown impurity at a level over the identification threshold of 0.1 %, and its structure was elucidated as 7-(3,5,6-trimethyl-1,4-benzoquinone- 2-yl)-7-p-tolyl-heptanoic acid based on the data of MS, UV, IR and NMR spectra. Formation of the unknown impurity as well as the countermeasure was also discussed | es |
dc.format.extent | 53-60 | es |
dc.language | en | es |
dc.subject | HPLC method; purity test; seratrodast related substances; structure characterization | es |
dc.subject | Cromatografia líquida de alta eficiencia | es |
dc.subject | Técnicas de Investigación | es |
dc.subject | Receptores de Tromboxanos | es |
dc.title | Related substances test and characterization of seratrodast in bulk drugs | es |
dc.type | Articulo | es |
sedici.identifier.uri | http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_8.pdf | es |
sedici.creator.person | Xu, Jufang | es |
sedici.creator.person | Hu, Yuzhu | es |
sedici.subject.materias | Farmacia | es |
sedici.description.fulltext | false | es |
mods.originInfo.place | Colegio de Farmacéuticos de la Provincia de Buenos Aires | es |
sedici.subtype | Articulo | es |
sedici.description.peerReview | peer-review | es |
sedici2003.identifier | ARG-FARM-ART-0000001588 | es |
sedici.relation.journalTitle | Latin American Journal of Pharmacy | es |
sedici.relation.journalVolumeAndIssue | vol. 30, no. 1 | es |