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dc.date.accessioned 2011-03-11T13:25:27Z
dc.date.available 2011-03-11T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10915/8119
dc.description.abstract The aim of the present study was to evaluate the in vitro toxicity of two multi wall carbon nanotubes (MWCNT) on human hepatocytes (Hep G 32 cell lines). The toxic effects of carbon nanoparticles were analyzed after 48 h of incubation with Hep G 32 cells using MTT assay and also estimated the levels of LDH (that is leakage into the media). The results of the LDH estimation demonstrated that exposure of multi wall carbon nanotubes to hepatocytes (Hep G 32) for 48 h resulted in concentration-dependent increase in LDH leakage and exhibited a significant (p < 0.05) cytotoxicity at 3-50 μg/ml. Incubation of carbon nanotubes with liver cells produced a dose dependent inhibition of growth of the cells. The TC50 or IC50 values (toxic concentration 50 i.e. concentration of particles inducing 50 %cell mortality) of two nanoparticles were found in the range of 36.99-37.15 μg/ml, which were less than that of quartz (known toxic agent, 39.85 μg/ml), indicating the toxic nature of carbon nanoparticles es
dc.format.extent p. 177-180 es
dc.language en es
dc.title In vitro cytotoxicity of carbon nanoparticles against Hep G 32 cells es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_3.pdf es
sedici.creator.person Anreddy, Rama N. R. es
sedici.creator.person Devarakonda, Krishna R. es
sedici.creator.person Vurimindi, Himabindu es
sedici.creator.person Yellu, Narsimha R. es
sedici.subject.materias Farmacia es
sedici.subject.decs Nanopartículas es
sedici.subject.descriptores Test de citotoxicidad es
sedici.subject.keyword carbon nanotubes; cytotoxicity; in vitro, Hep G 32; MWCNT es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001606 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 1 es


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