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dc.date.accessioned 2011-04-11T14:18:27Z
dc.date.available 2011-04-11T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8152
dc.description.abstract Ethanol and dichloromethane extracts from the marine sponge Iotrochota birotulata collected in the Urabá Gulf (Colombia) were tested against three human tumor cellular lines, including lung (A- 549), colon (HT29) and breast (MDA-MB-231), at 1 µg/mL, 5 µg/mL and 25 µg/mL. The most bioactive extract (ethanol), was separated by flash column chromatography obtaining six fractions which biological activity was evaluated on the same cellular lines A-549, HT29 and MDA-MB-231, at 1µg/mL, 5 µg/mL and 25 µg/mL. The bioassay results showed that both extracts and two of the fractions totally inhibited the growing of the cellular line A549 at 25 µg/mL, while the most active fraction showed total inhibition of the growing of the three tumor cell lines on the three evaluated concentrations. The most active fraction was separated by reversed phase HPLC which allowed isolating and then characterizing by mono- and bidimensional NMR, a halogenated compound derived from the bromotyrosine. es
dc.format.extent 392-396 es
dc.language en es
dc.subject bromotyrosine; Iotrochota birotulata; marine sponge es
dc.subject Extractos Vegetales es
dc.subject Línea Celular Tumoral es
dc.subject Técnicas y Procedimientos de Laboratorio es
dc.title Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia) es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_9.pdf es
sedici.creator.person Márquez, Diana M. es
sedici.creator.person Márquez Fernández, María Elena es
sedici.creator.person Martínez, Alejandro es
sedici.creator.person Thomas, Olivier P. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001639 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 2 es


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