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dc.date.accessioned 2011-04-25T17:14:31Z
dc.date.available 2011-04-25T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8159
dc.description.abstract The present study was undertaken to evaluate the comparative antidepressant activity of Ocimum sanctum (OS) and imipramine using animal models of depression. Imipramine (15 mg/kg/i.p) and herbal extract of OS (500 mg/kg/p.o) were subjected for its antidepressant activity using four different animal models of depression, viz: Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST) in male Wistar rats. The study after single administration of OS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to control respectively. However there was no significant potentiation of PST. The antidepressant activity of OS was comparable to that of standard drug imipramine. The results of the present study indicate the potential for use of OS as an adjuvant in the treatment of depression. es
dc.format.extent 435-439 es
dc.language en es
dc.subject antidepressant activity; imipramine; ocimum sanctum es
dc.subject Extractos Vegetales es
dc.subject Depresión es
dc.title Comparative pharmacological evaluation of ocimum sanctum and imipramine for antidepressant activity es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_3.pdf es
sedici.creator.person Moinuddin, Ghulam es
sedici.creator.person Devi, Kshama es
sedici.creator.person Satish, Hanumantharayashetty es
sedici.creator.person Khajuria, Deepak Kumar es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001646 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es


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