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dc.date.accessioned 2011-04-27T12:03:38Z
dc.date.available 2011-04-27T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10915/8173
dc.description.abstract The purpose of this study was to develop and validate analytical methods for determination of amlodipine besylate in tablets. Simple, accurate and precise liquid chromatographic and spectrophotometric methods are proposed. For the chromatographic method, the conditions were: a LiChrospher®100 RP-18 Merck® (125 mm x 4.6 mm, 5 µm) column; methanol/water containing 1 % of trietylamine adjusted to pH 5.0 with phosphoric acid (35:65) as mobile phase; a flow rate of 1.0 mL/min and UV detector at 238 nm. Linearity was in the range of 50.0 - 350.0 µg/mL with a correlation coefficient (r) = 0.9999. For the spectrophotometric method, the first dilutions of samples were performed in methanol and the consecutives in ultrapure water. The quantitation was made at 364.4 nm. Linearity was determined within the range of 41.0 - 61.0 µg/mL with a correlation coefficient (r) = 0.9996. Our results demonstrate that both methods can be used in routine analysis for quality control of tablets containing amlodipine besylate. es
dc.format.extent p. 527-533 es
dc.language en es
dc.title Quantitative determination of amlodipine besylate in tablets by high performance liquid chromatography and UV spectrophotometry es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_17.pdf es
sedici.creator.person Leite, Helen D. es
sedici.creator.person Santoro, Maria Ines Rocha Miritello es
sedici.creator.person Porto, João M.A. es
sedici.creator.person López García, Pedro es
sedici.creator.person Almeida, Mariana M. de es
sedici.creator.person Tavares, Vanessa F. es
sedici.creator.person Kedor-Hackmann, Erika R.M. es
sedici.subject.materias Farmacia es
sedici.subject.decs Técnicas de Química Analítica es
sedici.subject.decs Piridinas es
sedici.subject.keyword amlodipine besylate; chromatographic method; methods validation; spectrophotometric method es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001660 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 3 es


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