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dc.date.accessioned 2011-04-27T13:46:54Z
dc.date.available 2011-04-27T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8176
dc.description.abstract The hepatoprotective activity of ethanolic extract of the whole plant of Cayratia trifolia (L.) Domin was evaluated against nitrobenzene (NB) (50 mg/Kg bw, orally) induced hepatic damage in rats. The extract at the dose of 200 mg/kg body weight were administered orally once every day for 7 successive days. The treatment restores the elevated levels of the liver marker enzymes such as alanine amino transferase, aspartate amino transferase, alkaline phosphatase in serum and lipid peroxidation in tissue homogenate. Whereas the antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase remains decreased in carcinogen induced group and after treatment the levels of antioxidant enzymes increased. Histopathological analysis of the NB induced animals showed severe necrosis and fatty infiltration in liver. After treatment with C. trifolia the rats showed regeneration of hepatocytes. The results thus support the use of C. trifolia as a hepatoprotective agent. es
dc.format.extent 546-549 es
dc.language en es
dc.subject Extractos Vegetales es
dc.subject antioxidants; Cayratia trifolia (L.) Domin; histopathology; liver marker enzymes; nitrobenzene es
dc.title Hepatoprotective activity of Cayratia trifolia (L.) domin against nitrobenzene induced hepatotoxicity es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_1.pdf es
sedici.creator.person Guru Kumar, Dugganaboyana es
sedici.creator.person Sonumol, Vattachanakkal M. es
sedici.creator.person Rathi, Muthaiyan A. es
sedici.creator.person Thirumoorthi, Lakshmanan es
sedici.creator.person Meenakshi, Periasamy es
sedici.creator.person Gopalakrishnan, Velliyur K. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001663 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 3 es


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