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dc.date.accessioned 2011-05-10T13:03:09Z
dc.date.available 2011-05-10T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10915/8206
dc.description.abstract In the present study matrix and multilayered matrix tablets of diltiazem HCl were formulated by using guar gum as matrix core component and cellulose derivative, Sodium Carboxy Methyl Cellulose (SCMC) as barrier layers. Marked difference in dissolution characteristics of D3 and D3L3 was observed and showed a statistically significant difference. The study revealed that the matrix tablets prolonged the release, but predominantly in a first order fashion. Layering with SCMC granules on the matrix core, provided linear drug release with zero order kinetics. Mean dissolution time for D3 and D3L3 were found to be 4.17 h and 16.45 h, while dissolution efficiency decreased, indicating slower drug release. In vivo transit time of the formulation D3L3 shows that it crossed the small intestine at 6 h and retained for longer time in colon at 12 h. FT-IR and DSC studies show there is no drug-excipeints interaction. Stability studies portray that no change either in physical manifestation or in dissolution profile after storage at 40 ± 2 °C/RH 75 ± 5 % for 3 and 6 months. es
dc.format.extent p. 721-728 es
dc.language en es
dc.title Formulation and evaluation of multilayered matrix tablets of diltiazem hydrochloride es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_14.pdf es
sedici.creator.person Mangamoori, Lakshmi N. es
sedici.creator.person Yamsani, Madhusudan R. es
sedici.subject.materias Farmacia es
sedici.subject.decs Disolución es
sedici.subject.decs Estabilidad de Medicamentos es
sedici.subject.decs Bloqueadores de los Canales de Calcio es
sedici.subject.keyword controlled release; cellulose derivatives; diltiazem hcl; multilayered matrix tablets es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001693 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 4 es

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