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dc.date.accessioned 2011-06-21T12:39:48Z
dc.date.available 2011-06-21T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8225
dc.description.abstract The objective of the work was to develop, optimize and evaluate self-microemulsifying drug delivery system (SMEDDS) of carvedilol (CDL), a poorly water-soluble drug. SMEDDS was developed to increase the solubility, dissolution rate and ultimately, oral bioavailability of CDL. The solubility of CDL was determined in various oils, surfactants and cosolvents. Pseudoternary phase diagrams were used to identify the region of microemulsification. The SMEDDS were characterized by morphological observation, droplet size and zeta-potential, cloud point, % transmission study and emulsification time. The optimized formulation was composed of Capmul MCM C8 (18 %), Tween 80 (65.6 %), and polyethylene glycol 400 (14.4 %). The SMEDDS formulation showed complete release in 20 min as compared with the plain drug, which showed a limited dissolution rate. es
dc.format.extent 837-843 es
dc.language en es
dc.subject carvedilol; polyethylene glycol 400; capmul MCM C8 es
dc.subject Sistemas de Liberación de Medicamentos es
dc.subject Formas de Dosificación es
dc.title Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_1.pdf es
sedici.creator.person Rao, Monica es
sedici.creator.person Munjapara, Ghanshyam S. es
sedici.creator.person Khole, Ishwar A. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001712 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 5 es


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