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dc.date.accessioned | 2011-06-21T13:19:33Z | |
dc.date.available | 2011-06-21T03:00:00Z | |
dc.date.issued | 2011 | es |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/8227 | |
dc.description.abstract | This work evaluated the influence of B-cyclodextrin (B-CD) on Eudragit® FS 30 D (FS) free film-forming capacity in the following blends: 90:10 and 95:5 (FS: B-CD) as material for potential application in colonic drug delivery systems. A control film (FS 100 %) was also prepared. Determination of swelling index (Is%) and permeability and physicochemical analysis were carried out. Formulations containing 95:5 or 90:10 FS: B-CD ratio and about 5 % of glyceryl monostearate (GMS) as a glidant provided homogeneous, continuous, and flexible films. Water vapour transmission (WVT) increased with an increase in B-CD concentration. On the other hand, how major was the B-CD amount lower was found the Is% for the film. Physicochemical analysis using TG revealed an initial thermal decomposition temperature shift that indicated lower thermal stability for films with 90:10 or 95:5 FS: B-CD ratio compared with the control (100:0). The results of FT-IR did not give evidence of any intermolecular interaction between B-CD and the acrylic polymer, showing just a physical mixture of both components in formulation. | es |
dc.format.extent | 853-856 | es |
dc.language | en | es |
dc.subject | B-cyclodextrin; eudragit® FS 30 D; free film | es |
dc.title | Free films containing acrylic polymer and B-cyclodextrin as potential material for colonic delivery: permeability, swelling property, and physicochemical analyses | es |
dc.type | Articulo | es |
sedici.identifier.uri | http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_3.pdf | es |
sedici.creator.person | Oliveira, Luciana S. | es |
sedici.creator.person | Jesus, Liana I. | es |
sedici.creator.person | Hechenleitner, Ana A. W. | es |
sedici.creator.person | Albuquerque Cavalcanti, Osvaldo | es |
sedici.subject.materias | Farmacia | es |
sedici.description.fulltext | false | es |
mods.originInfo.place | Colegio de Farmacéuticos de la Provincia de Buenos Aires | es |
sedici.subtype | Articulo | es |
sedici.description.peerReview | peer-review | es |
sedici2003.identifier | ARG-FARM-ART-0000001714 | es |
sedici.relation.journalTitle | Latin American Journal of Pharmacy | es |
sedici.relation.journalVolumeAndIssue | vol. 30, no. 5 | es |