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dc.date.accessioned 2011-06-21T15:16:31Z
dc.date.available 2011-06-21T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8231
dc.description.abstract A novel polymer, chemically modified chitosan was synthesized by reacting with hydrochloride salt of 2-aminoethanoyl chloride. Formation of novel chemically modified chitosan was confirmed by FTIR and NMR spectroscopy and by thermal (DSC) and elemental analysis. Acute oral toxicity study was performed on modified chitosan to check its safety. Ibuprofen, paracetamol and diclofenac sodium tablets were compressed on a single punch tablet machine using the weight granulation method. The drug release was found to be delayed from the formulations containing chemically modified chitosan. Thus, it could be concluded that the change in the hydrophilic balance and the resultant change in the modulation of swelling of the polymer may retard the drug release from polymer matrices. es
dc.format.extent 882-889 es
dc.language en es
dc.subject acylation; 2-aminoethanoyl chloride; chitosan; drug release es
dc.subject Polisacáridos es
dc.subject Procesos Bioquímicos es
dc.subject Sistemas de Liberación de Medicamentos es
dc.title Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_7.pdf es
sedici.creator.person Aloorkar, Nagesh H. es
sedici.creator.person Bhatia, Manish S. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001718 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 5 es


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