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dc.date.accessioned 2011-06-27T17:42:30Z
dc.date.available 2011-06-27T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10915/8241
dc.description.abstract This work is focused on the development of a new particulate drug delivery system using sodium alginate (SA) and modified hydrophobic hydroxyl propyl methyl cellulose (HPMC, 60L grade) containing diclofenac as a model drug molecule for intestinal drug prolonged release. Diclofenac loaded HPMC-SA beads have been developed by ion exchange methods and were characterized by encapsulation efficiency, drug release profile, swelling and matrix erosion rate. Matrix swelling of calcium alginate beads induced by phosphate buffer ends up in erosion and destruction. However, for HPMC-SA beads do not lead to complete erosion, which may be the main cause of diclofenac retention within the matrix. The release of diclofenac potassium is negligible at acidic pH, while is complete in 5-6 h when pH is raised up to 7.4. The alginate/HPMC ratio controls the release rate of the drug. The drug release is decreased as the polymer concentration is increased from 2.5 to 3.5 %. Release kinetic study was done to understand the correlation between the formulations. The results show that drug release is diffusion controlled and it is Anomalous type which means combined process of both swelling and erosion of polymer. es
dc.format.extent p. 945-951 es
dc.language en es
dc.title Alginate/hydrophobic HPMC (60L) particulate systems: new matrix for controlled release of diclofenac potassium es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_17.pdf es
sedici.creator.person Ray, Sarbani D. es
sedici.creator.person Ghosal, Kajal es
sedici.creator.person Ghosal, Ingana es
sedici.creator.person Ghosh, Dipanwita es
sedici.subject.materias Farmacia es
sedici.subject.decs Sistemas de Liberación de Medicamentos es
sedici.subject.decs Metilcelulosa es
sedici.subject.decs Éteres es
sedici.subject.decs Diclofenaco es
sedici.subject.keyword beads; diclofenac; hydrophobic HPMC; sodium alginate; swelling es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001728 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 5 es


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