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dc.date.accessioned 2011-06-28T18:12:47Z
dc.date.available 2011-06-28T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10915/8251
dc.description.abstract The transport of buspirone across rat intestine (duodenum, jejunum, ileum and colon) was studied by using the non-everted sac method. Rats were pretreated with ashwagandha (Withania somnifera) and Aloe vera juice for 7 days. The rats were sacrificed by using anesthetic ether, the intestinal segments were isolated and used for the studies. The probe drug (buspirone) solution was placed in the isolated intestinal sac. Samples were collected at preset time points and replaced with fresh buffer. The drug content in the samples was estimated using high performance liquid chromatography method. Control experiments were also performed. The results reveal that there was a significant (p < 0.05) difference compared to control, in the transport of buspirone from the intestinal sacs which were pretreated with ashwagandha and Aloe vera juice. It suggests that both ashwagandha and Aloe vera might be acting by inhibiting the transporters and enzymes which are responsible for transport/metabolism of buspirone. es
dc.format.extent p. 1005-1009 es
dc.language en es
dc.title Effect of ashwagandha and aloe vera pretreatment on intestinal transport of buspirone across rat intestine es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_4.pdf es
sedici.creator.person Yamsani, Shravan K. es
sedici.creator.person Devandla, Adukondalu es
sedici.creator.person Yamsani, Vamshi V. es
sedici.creator.person Athukuri, Bhargavilatha es
sedici.creator.person Gannu, Ramesh es
sedici.creator.person Palem, Chinna R. es
sedici.creator.person Rao , Yamsani Madhusudan es
sedici.creator.person Manda, Sarangapani es
sedici.subject.materias Farmacia es
sedici.subject.decs Extractos Vegetales es
sedici.subject.decs Agentes Ansiolíticos es
sedici.subject.descriptores Cromatografia líquida de alta eficiencia es
sedici.subject.keyword aloe vera; ashwagandha; buspirone; CYP3A; noneverted sac; p-glycoprotein, withania somnifera es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001738 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 5 es


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