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dc.date.accessioned 2011-06-30T18:58:07Z
dc.date.available 2011-06-30T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8258
dc.description.abstract Didanosine (ddI) is an important drug in the AIDS therapy. However, to overcome the instability of ddI in acid medium, the tablets have a large amount of buffer that can lead to side effects such as diarrhea and kidney problems. Microencapsulation of ddI can reduce the excessive use of buffers. In this work we used the ionotropic gelation technique in the preparation of chitosan microspheres. The microspheres were characterized according to the incorporation efficiency, loading capacity, degree of swelling, permeability and morphology. The best results were obtained for 10 g of chitosan/g of sodium tripolyphosphate. Subsequently, changes were carried out in the agitation system in order to optimize it. Such changes were able to improve the incorporation efficiency as well as reduce the energy consumption of the system. es
dc.format.extent 1037-1040 es
dc.language en es
dc.subject chitosan; ddI; didanosine; ionotropic gelation es
dc.title Didanosine-loaded chitosan microspheres: optimization of fabrication process es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_11.pdf es
sedici.creator.person Silva, Classius F. da es
sedici.creator.person Severino, Patrícia es
sedici.creator.person Martins, Fernanda es
sedici.creator.person Santana, Maria H. A. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001745 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 5 es

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