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dc.date.accessioned 2011-08-29T12:33:17Z
dc.date.available 2011-08-29T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8281
dc.description.abstract Hydrophilic matrix tablets were developed with carvedilol (CRV), using different molecular weights of polyethylene oxide (PEO). Investigations were carried out in order to verify the tablets performance. All formulations satisfied the official requirements. Water uptake studies were influenced by pH value and polymer concentration. CRV release was sustained for 23 and 19 h, in acid and neutral conditions, respectively. The mechanism involved in drug release was characterized by anomalous behavior for all formulations in phosphate buffer whereas in acid conditions they presented a Fickian kinetics, Case II transport and Super Case II transport kinetics for different formulations. es
dc.format.extent 1202-1207 es
dc.language en es
dc.subject carvedilol; matrix tablets; polyethylene oxide; release behavior es
dc.subject Receptores beta Adrenérgicos es
dc.subject Sistemas de Liberación de Medicamentos es
dc.title Development and evaluation of carvedilol/ polyethylene oxide matrix tablets es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_23.pdf es
sedici.creator.person Barboza, Fernanda M. es
sedici.creator.person Stulzer, Hellen Karine es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001768 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 6 es


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