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dc.date.accessioned 2011-08-29T13:44:13Z
dc.date.available 2011-08-29T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8283
dc.description.abstract Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to investigate drug-excipient interactions and, in consequence, their compatibility. For this purpose, binary mixtures of olanzapine drug substance and the excipients croscarmellose sodium, magnesium stearate and microcrystalline cellulose, were prepared and analysed. By the analysis of the binary mixtures DSC and TG curves it were observed changes on the temperature and enthalpy values of the drug melting and decomposition peak, with the likely formation of intermediate substances. es
dc.format.extent 1211-1215 es
dc.language en es
dc.subject Excipientes Farmacéuticos es
dc.subject compatibility; DSC; excipient; olanzapine; TGA; thermal analysis es
dc.subject Técnicas de Química Analítica es
dc.title Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_2_2.pdf es
sedici.creator.person Marques, Lucas M. M. es
sedici.creator.person Medeiros, Maria G. F. de es
sedici.creator.person Nunes, Lívio C. C. es
sedici.creator.person Citó, Antônia M.G.L. es
sedici.creator.person Lopes, José A. D. es
sedici.creator.person Souza, Alexandre A. es
sedici.creator.person Souza, Claide M. L. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001770 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 6 es


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