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dc.date.accessioned 2011-08-30T11:48:18Z
dc.date.available 2011-08-30T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8288
dc.description.abstract The present study was performed to compare the bioavailability of two digoxin 0.25 mg tablet formulation in 30 volunteers of both sexes. The study was conducted open with randomized two period crossover design and a three-week washout period. Plasma samples were obtained over a 144 h interval. Digoxin concentrations were analyzed by a validated microparticle enzyme immunoassay with optical detection by fluorescence. Bioequivalence between the products was determined by calculating 90 % confidence intervals (90 % I.C) for the ratio of AUC0-72h and Cmax values for the test and reference products, using logarithmic transformed data. The 90 % confidence intervals were 86.98-118.33 %, and 84.52–98.76 %, respectively. Since the 90 % confidence intervals for Cmax and AUC0-72h were within the 80-125 % interval proposed by Food and Drug Administration, it was concluded that the two Digoxin formulations are bioequivalent in their rate and extent of absorption. es
dc.format.extent 1234-1238 es
dc.language en es
dc.subject bioequivalence; digoxin; pharmacokinetics; volunteers es
dc.subject Farmacocinética es
dc.subject Glicósidos Cardíacos es
dc.subject Inmunoensayo es
dc.title Comparative bioavailability of two digoxin formulations: determination in human plasma by microparticle enzyme immunoassay es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_2_7.pdf es
sedici.creator.person Junior, Eduardo A. es
sedici.creator.person Duarte, Luciana F. es
sedici.creator.person Vanunci, Moisés L. P. es
sedici.creator.person Silva, Lara C. es
sedici.creator.person Pereira, Renata es
sedici.creator.person Calafatti, Silvana es
sedici.creator.person Junior, José P. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001775 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 6 es

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