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dc.date.accessioned 2011-09-28T13:18:29Z
dc.date.available 2011-09-28T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10915/8295
dc.description.abstract In the present study, mucilage from leaves of Hibiscus rosa-sinensis L. was extracted and physico-chemical parameters like swelling ratio and angle of repose were determined. Diclofenac sodium matrix tablets containing dried mucilage of H. rosa-sinensis were prepared by direct compression (hydrophilic and hydrophobic). Level and type of excipients influence on drug release, as well as water uptake and mass loss studies were carried out. Stability study of tablets was carried out at 40 °C and 75 % RH for three months. The dried mucilage powder shows superior swelling in all three different media. Batches H and N full fills the entire set criterion. Drug release kinetics from these formulations corresponded best to the zero-order kinetics. There was no significant effect of agitation speed on water uptake while mass loss was significantly affected by agitation speeds of prepared tablets. Tablets are stable after storage. es
dc.format.extent p. 1283-1290 es
dc.language en es
dc.title Influence of excipient type and level on quality control parameters of tablets formulated from polysaccharides matrix system es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_5.pdf es
sedici.creator.person Shah, Dhiren P. es
sedici.creator.person Jani, Girish K. es
sedici.subject.materias Farmacia es
sedici.subject.decs Hibiscus es
sedici.subject.decs Fenilacetatos es
sedici.subject.decs Extractos Vegetales es
sedici.subject.keyword diclofenac sodium; hibiscus rosa-sinensis L.; in vitro drug release; water uptake and mass loss es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001782 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 7 es


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