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dc.date.accessioned 2011-10-06T14:38:25Z
dc.date.available 2011-10-06T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8322
dc.description.abstract 4'-ethyl-7-phenylsulfonylgenistein (EPG, 3), a potential prodrug for genistein (1), was synthesized in high yield and its crystal structure was reported firstly. It possesses better physical and chemical properties such as solubility, lipid/water partition coefficient, LogP, and hydrolysis kinetics than its original form. The LogP value (2.07) and the half-life of the hydrolysis value (13.4 h) show that its oral bioavailability is possibly improved evidently compared with that of genistein. These results indicate that EPG can be considered a potential prodrug for genistein. es
dc.format.extent 1449-1453 es
dc.language en es
dc.subject Isoflavonas es
dc.subject crystal structure; genistein benzensulfonate; hydrolysis; partition coefficient; prodrug es
dc.subject Psicofarmacología es
dc.subject Farmacocinética es
dc.title Preparation, crystal structure and prodrug studies of genistein benzensulfonate es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_2_7.pdf es
sedici.creator.person Peng, You es
sedici.creator.person Gan, Li- Jun es
sedici.creator.person Deng, Ze-yuan es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001809 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 7 es

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