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dc.date.accessioned 2011-11-10T13:48:10Z
dc.date.available 2011-11-10T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8331
dc.description.abstract Zidovudine is a drug used for the treatment of AIDS. The objective of this work was to prepare tablets for modified release of zidovudine. Hydroxypropyl methylcellulose HPMC K100LV and HPMC K4M at 12.50 %, 18.75 % and 25.00 % were used. The tablets produced with 12.50 % of HPMC reached 100 % of the zidovudine release in 6 hours, while those produced with 18.75 and 25.00 %, released 24 h, following the Higuchi and First Order kinetic models, respectively. The calculated release exponent pointed out that formulations follow the anomalous type of release mechanism, with a combined phenomena of diffusion and erosion. es
dc.format.extent 1512-1518 es
dc.language en es
dc.subject hydroxypropyl methylcellulose; modified release; zidovudine es
dc.subject Timidina es
dc.subject Sistemas de Liberación de Medicamentos es
dc.title Preparation and evaluation of modified release zidovudine tablets es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_9.pdf es
sedici.creator.person Bicheri, María T. L. es
sedici.creator.person Chaud, Marco Vinicius es
sedici.creator.person Gonçalves, Marcos M. es
sedici.creator.person Vila, Marta M. D. C. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001818 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 8 es


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