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dc.date.accessioned 2011-12-19T17:51:48Z
dc.date.available 2011-12-19T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10915/8368
dc.description.abstract D-004, a lipid extract from Roystonea regia fruits, consists in a mixture of free fatty acids, mainly of oleic, lauric, myristic and palmitic acids, whereas other free fatty acids are present in minor proportions. D-004 has been shown to reduce experimentally-induced prostate hyperplasia and to produce anti-inflammatory effects in a chronic inflammation model. The effects of D-004 on models of acute inflammation, however, have not been explored. This study investigated the effects of single oral doses of D-004 on the model of xylene-induced ear mice oedema. Mice were distributed into 6 experimental groups: one negative control and five xylene-treated groups: one positive control (vehicle), three treated with D-004 (100, 400 and 800 mg/kg) and one with indomethacin (10 mg/kg). Effects on oedema formation and myeloperoxidase (MPO) activity were assessed. D-004 at 400 and 800 mg/kg significantly reduced both variables. The reduction of MPO activity, not of oedema formation, was dose-dependent. Concluding, D- 004 was effective as anti-inflammatory drug on the xylene-induced ear mice oedema, a model of acute inflammation. es
dc.format.extent p. 1744-1748 es
dc.language en es
dc.title Effect of oral administration of D-004, a lipid extract from Roystonea regia Fruits, on xylene-induced ear oedema in mice es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_12.pdf es
sedici.creator.person Ravelo, Yazmin es
sedici.creator.person Molina, Vivian es
sedici.creator.person Jiménez, Sonia es
sedici.creator.person Oyarzábal, Ambar es
sedici.creator.person Pérez, Yohani es
sedici.creator.person Más, Rosa es
sedici.subject.materias Farmacia es
sedici.subject.keyword D-004; inflammation; myeloperoxidase; xylene-induced oedema es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001855 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 9 es


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