Subir material

Suba sus trabajos a SEDICI, para mejorar notoriamente su visibilidad e impacto


Mostrar registro sencillo 2011-12-19T17:51:48Z 2011-12-19T03:00:00Z 2011 es
dc.description.abstract D-004, a lipid extract from Roystonea regia fruits, consists in a mixture of free fatty acids, mainly of oleic, lauric, myristic and palmitic acids, whereas other free fatty acids are present in minor proportions. D-004 has been shown to reduce experimentally-induced prostate hyperplasia and to produce anti-inflammatory effects in a chronic inflammation model. The effects of D-004 on models of acute inflammation, however, have not been explored. This study investigated the effects of single oral doses of D-004 on the model of xylene-induced ear mice oedema. Mice were distributed into 6 experimental groups: one negative control and five xylene-treated groups: one positive control (vehicle), three treated with D-004 (100, 400 and 800 mg/kg) and one with indomethacin (10 mg/kg). Effects on oedema formation and myeloperoxidase (MPO) activity were assessed. D-004 at 400 and 800 mg/kg significantly reduced both variables. The reduction of MPO activity, not of oedema formation, was dose-dependent. Concluding, D- 004 was effective as anti-inflammatory drug on the xylene-induced ear mice oedema, a model of acute inflammation. es
dc.format.extent p. 1744-1748 es
dc.language en es
dc.title Effect of oral administration of D-004, a lipid extract from Roystonea regia Fruits, on xylene-induced ear oedema in mice es
dc.type Articulo es
sedici.identifier.uri es
sedici.creator.person Ravelo, Yazmin es
sedici.creator.person Molina, Vivian es
sedici.creator.person Jiménez, Sonia es
sedici.creator.person Oyarzábal, Ambar es
sedici.creator.person Pérez, Yohani es
sedici.creator.person Más, Rosa es
sedici.subject.materias Farmacia es
sedici.subject.keyword D-004; inflammation; myeloperoxidase; xylene-induced oedema es
sedici.description.fulltext false es Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001855 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 9 es

Descargar archivos

Este ítem aparece en las siguientes colecciones: